Light Induced Visual-Response: Novel Biomarker of Retinal Function – Reproducibility and its Correlation with Retinal Ischemia

A Webinar with Suber S. Huang, MD, MBA and John Wroblewski, MD New peer-reviewed evidence shows Diopsys^® ffERG/Flicker parameters significantly correlate with other markers of diabetic retinopathy, such as fluorescein angiography.¹ This correlation may allow clinicians to establish an easy, useful surrogate biomarker with an in-office, non-invasive test that is sensitive to disease progression and improvement.^2-7 Please join Dr. Huang and Dr. Wroblewski to learn how this objective, functional test may help doctors determine therapeutic efficacy, offering a more subtle and precise look into treatment – whether to continue therapy, adjust dosing, or to discontinue.

1. Wroblewski, John J., et al. “Reproducibility of Fixed-Luminance and Multi-Luminance Flicker Electroretinography in Patients With Diabetic Retinopathy Using an Office-Based Testing Paradigm.” Journal of Diabetes Science and Technology, Oct. 2019, doi:10.1177/1932296819882719. 2. Bresnick GH, Palta M. Temporal aspects of the electroretinogram in diabetic retinopathy. Arch Ophthalmol. 1987;105:660-664. 3. Holopigian K, et al. Evidence for photoreceptor changes in patients with diabetic retinopathy. Invest Ophthalmol Vis Sci. 1997;38:2355-65. 4. Kim SH, et al. Electroretinographic evaluation in adult diabetics. Doc Ophthalmol. 1997-1998;94:201-13. 5. Pescosolido N, et al. Role of Electrophysiology in the Early Diagnosis and Follow-Up of Diabetic Retinopathy. J Diabetes Res;2015:319692. 6. Tzekov R, Arden GB. The Electroretinogram in Diabetic Retinopathy. Surv Ophthalmol 1999, 44:53-60. 7. Holm K, et al. Peripheral retinal function assessed with 30-Hz flicker seems to improve after treatment with Lucentis in patients with diabetic macular oedema. Doc Ophthalmol. 2015;131:43-51.